New analysis, by a group of researchers including IGP's Michel van Eeten, suggests that by focusing mitigation efforts on a subset of ISPs could eliminate the bulk of zombie computers responsible for generating spam and initiating other online threats.
As reported in MIT Technology Review:

The researchers analyzed more than 63 billion unsolicited e-mail messages sent over a four-year period and found more than 138 million unique internet addresses linked to sending out the spam. Typically such machines have been hijacked by hackers and are corralled into a vast network of remote-controlled system known as a “botnet.”

By correlating the Internet protocol addresses of these spam-sending machines with the networks maintained by Internet service providers, the researchers found that about two-thirds of them were located in the networks managed by the 200 largest ISPs from 40 countries. The top-50 networks responsible accounted for more than half of all compromised IP addresses. If these ISPs were to shut down, or block, the malicious machines on their networks, it could cut worldwide spam by half.

“Those 50 ISPs are not the [dubious] ones we hear about,” says Michel van Eeten, professor of public administration at the Delft University of Technology in the Netherlands and one of the authors of a paper on the research, which will be presented next month at the Workshop on the Economics of Information Security at Harvard University. “They are the ones we deal with every day, and so are more approachable and are in the reach of government.”